Job Description

General Description

Are you excited to explore a yet-to-be-solved problem at the heart of recombinant adeno-associated virus (rAAV) manufacturing? Join Michael Betenbaugh's research lab to develop and mature some of the most in-demand research skills in academia and industry today.

We are seeking a highly motivated and skilled Postdoctoral Researcher to join our dynamic research team. The successful candidate will lead a project focused on improving production of rAAV using the Sf9/recombinant baculovirus (rBV) and HEK-293 expression system to achieve higher yields of high-quality and functionally active rAAV by applying computational modelling and complementary analytical and molecular biology techniques. A Ph.D. in Chemical Engineering, Biological Sciences, Bioengineering, or a related field is desired.

• Johns Hopkins offers an unmatched environment for life sciences research, with a dynamic community in biomolecular engineering, biophysics, biochemistry, and medicine.
• Standard benefits
• Baltimre is one of the most affordable and livable cities on the US East Coast
• The Betenbaugh laboratory offers unmatched opportunities to collaborate with industrial partners in the biopharma and biotech industry
• Be part of the AMBIC biomanufacturing center (Prof. Betenbaugh serves as the Center Director), and you will be able to participate in AMBIC Conferences, workshops, and seminars.
• Lab alumni have advanced to positions in industry giants (Genentech, Merck, Pfizer, GSK), and recent startups (Drul, Biolinco).
• Initial appointment period of one year, with expectation of 2 or more years total.
• Supportive mentoring environment, with regular 1:1 meetings with Dr. Betenbaugh

More information about the Betenbaugh Lab at:

Key responsibilities could include, but are not limited to, assisting in the following:

• Conduct literature reviews on rAAV production technologies, computational modeling, and advanced analytical techniques.

-         Design  and perform experiments to evaluate strategies for optimizing rAAV production.

• Develop and/or apply computational models to identify and address bottlenecks in the rAAV manufacturing process.
• Perform data analysis and interpretation to guide experimental and computational efforts.

-         Prepare and present research findings through journal articles, conference presentations, and internal reports.

• Maintain detailed documentation of experimental and computational workflows, results, and methodologies. Communicate results with industrial collaborators
• Assist in mentoring graduate students and junior researchers on the team.

Qualifications

• PhD in Chemical Engineering, Biological Sciences, Bioengineering, or a related field
• Background in molecular biology, virology, and protein expression helpful
• Capacity to manipulate baculovirus and rAAV t

- Advanced microscopy, mathematical modeling, and machine learning techniques.

- Proficiency in data analysis, statistical modeling, and experimental design.

Ability to work collaboratively in a multidisciplinary team environment.

Application Instructions

In Interfolio, applicants should upload a CV, cover letter detailing their research experience and interests, and contact information for three references. The statement should state why the Betenbaugh lab is a good fit for your career trajectory.

About Johns Hopkins University

Johns Hopkins University remains committed to its founding principle, that education for all students should be grounded in exploration and discovery. Hopkins students are challenged not just to learn but also to advance learning itself. Critical thinking, problem solving, creativity, and entrepreneurship are all encouraged and nourished in this unique educational environment. After more than 130 years, Johns Hopkins remains a world leader in both teaching and research. Faculty members and their research colleagues at the university's Applied Physics Laboratory have each year since 1979 won Johns Hopkins more federal research and development funding than any other university. The university has nine academic divisions and campuses throughout the Baltimore-Washington area. The Krieger School of Arts and Sciences, the Whiting School of Engineering, the School of Education and the Carey Business School are based at the Homewood campus in northern Baltimore. The schools of Medicine, Public Health, and Nursing share a campus in east Baltimore with The Johns Hopkins Hospital. The Peabody Institute, a leading professional school of music, is located on Mount Vernon Place in downtown Bal ... timore. The Paul H. Nitze School of Advanced International Studies is located in Washington's Dupont Circle area.

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